Skip to content

You are here:Home arrow Nutrition arrow General Nutrition Articles arrow Seperating Worthless Creatine from Creatine that Works
Seperating Worthless Creatine from Creatine that Works E-mail
Written by Lynn Glenn   

creatineCreatine is a supplement used by athletes, bodybuilders, and others who wish to gain muscle mass, and strength. Creatyine supplements are important because approximately 95% of the human body's total creatine is located in skeletal muscle and when building muscle the body cannot make enough creatine from the food we eat . This is why creatine supplementation can be of importance to those seeking muscle and strength gains.

Because it is widely known that creatine supplementation works so well, a huge number of companies came onto the scene to sell creatine, however many of the products that came to market were created in an unusable form.


Choosing a Creatine Product that Works

You certainly can't tell which creatine is the best by looking at all those crazy ads cramming the magazines each month. Each one sounds like it's the latest "miracle". And now with Kre-Alkalyn® EFX in the mix, you're probably even more confused.

As popular as creatine has become over the past decade or so, there has been very few if any articles explaining how creatine is actually is made. Once you understand how creatine is made, all the mystery (and the hype) surrounding these so called "new" creatines will suddenly disappear. What is meant by "new" creatine is that it's anything other than standard Creatine Monohydrate.

Separating the Real Facts from Fiction about Creatine

If there's one thing supplement users are starving for, it's credible information - especially about creatine. Let's clear the air by looking at the hard facts about what it takes to manufacture Kre-Alkalyn® EFX and other "Next Generation", "New", and "Better" creatines.

How Creatine is Made

Creatine is made in the body by combining three amino acids:creatine_book Glycine, Arginine, and Methionine. Chemically, it is called "a-methyl-guanidinoacetic acid" (C4H9N3O2). Creatine is also found in red meat, but extracting large enough amounts for commercial use would be very impractical. So Synthetic Creatine was manufactured. Synthetic creatine is manufactured from two chemicals: Sarcosine (a sodium salt and derivative of acetic acid; also called methyl-glycoccol) and Cyanamide (an organic amide...not to be confused with the similar sounding poison Cyanide).

Creatine Manufacturing Facts

FACT #1: Reacting the chemicals Sarcosine with Cyanamide in a medium of water, inside a glass-lined reactor, is the only way to make synthetic creatine. Creatine must be made in a vessel called a reactor. A reactor is a large, steel glass lined vat that's specifically used for mixing chemicals.

FACT #2: All synthetic creatine is manufactured or "synthesized" the same way. The process for synthesizing creatine has been nearly the same since the 1800's. Advancements in technology have allowed for improvements in the process with regard to the quality of the finished product. The Final Result, we have a dry, pure finished creatine ready to be bottled or encapsulated. Pure finished creatine is usually 88% creatine and 12% water because creatine picks up and bonds to water molecules during the initial reaction process.

FACT #3: Just like 2 + 2 always equals 4...the end result of the creatine manufacturing process is ALWAYS Creatine Monohydrate. You CANNOT make any other form of creatine from scratch.

An Eye-Opening Look at All the Various "New" Creatines

It's time to get to the "new" creatines on the market: Creatineall-american-efx-kre-alkalyn Titrate, Creatine Malate, Creatine Alpha-Ketoglutarate, Creatine Ethyl Ester, di-Creatine Malate...and now even tri-Creatine Malate, just to name a few. And lets add Kre-Alkalyn® EFX to the list too. Some ads for products that contain these creatine forms claim they're better and even more powerful than the time-tested standard, Creatine Monohydrate. However, the facts just don't agree...there is only one way to make synthetic creatine. And the end result of that process is always Creatine Monohydrate.

FACT #4: To create a "new" form of creatine, you must take FINISHED Creatine Monohydrate and react it all over again in water with the desired bonding compound, inside a glass-lined reactor. This is precisely where many problems arise from both a manufacturing and a scientific standpoint.

Here's an example of how Creatine Malate might be manufactured. Creatine Malate is supposed to be a combination of Creatine Monohydrate and Malic Acid chemically bonded to form the new compound. Bonding is critical to this point because it MUST happen to form true Creatine Malate. Even though this is essentially the same process described earlier for synthesizing creatine, there's a major problem with it this time around...

FACT #5: Creatine Monohydrate is unstable in liquids and acids. It undergoes a chemical conversion to creatinine - a mostly useless byproduct. Furthermore, creatine can't be bound to an acid because the acid destroys the creatine.

Where before water was the medium in which the reaction takes place in, water now becomes the catalyst that causes the reaction...only this time the reaction is with the creatine itself.

What happens is the creatine actually "falls apart" once it's activated by liquids and turns into something called creatinine - a mostly useless byproduct - that cannot enter the muscle cell.  Simply put, whatever amount you scoop out of the bottle isn't the same amount getting to your muscle cells.  In other words, it loses its potency during transport to your muscles.

 What Then Are All These "New" Creatines?

At best, they are actually one of three things:

1) Ordinary Creatine Monohydrate labeled as something else.

2) A simple mixture of Creatine Monohydrate and the acid it's supposedly bonded with.

3) A botched version created by a manufacturer who tried to "bond" Creatine Monohydrate to an acid without knowing the associated problems.

Furthermore, terms such as, "di" and "tri", as they relate to creatine, are simply made up. If anything, these "new" creatines should actually be called, Creatinine Titrate, Creatinine Malate, Creatinine Alpha-Ketoglutarate, Creatinine Ethyl Ester, di-Creatinine Malate...and tri-Creatinine Malate.  

FACT #6: Simply mixing or blending Creatine Monohydrate with another compound does not create a new form of creatine. You can't just "push" them together. In order to create the new compound...a chemical reaction must take place via a catalyst.

The "new" creatines are usually just a simple mixture (also called an "admixture") of Creatine Monohydrate and a powered form of the acid it's supposedly bonded with. Mixing compounds together does NOT make something new because there is no chemistry involved. At least, not until you add a catalyst.  When you add water (a catalyst) to it, you're causing a chemical reaction to take place that creates Creatinine Malate and Creatinine Citrate because the creatine portion is converting to creatinine and then bonding to the acids.

FACT #7: You cannot make pure creatine more powerful than it already is. Forget those claims about how one creatine form is 10 times...20 times... or even 40 times better than ordinary creatine. The most powerful creatine is actually one that starts with 100% potency, and then stays that way once you take it.

FACT #8: You cannot force a muscle cell to accept creatine beyond its physiological capacity. Once a muscle cell reaches maximum capacity, that's it. Don't fall for the claims some products are making that they contain certain forms of creatine or special nutrients that will expand muscle cells, or the pathways that lead to muscle cells, so they will absorb more.

FACT #9: Creatine Monohydrate is the ONLY form of creatine backed by 200+ studies, with over 70 published in peer-reviewed journals. Creatine is the single most studied sports supplement ever.  

FACT #10: The biggest problem in the sports nutrition industry today is the fact that almost no one tests their products for impurities, to guarantee they meet label claims, etc. If they do, it is likely not on a consistent basis.

FACT #11: When it comes to creatine products, everything comes down to just one word: quality.

Anyone can claim that they test. But what really matters is how they actually do the test. To fully understand the concept of testing, you need to know the differences between all the methods available.

HPLC Testing Method

The most commonly used form of testing in the supplement industry is HPLC (High Performance Liquid Chromatography). The greatest strength of this testing method is determining the purity of a compound. It measures the compound based on the pattern it gives off in a liquid state.

HPLC has four basic weaknesses:

1) It can only look for one compound in a sample at a time.

2) It cannot examine the entire sample in its entirety, "as is". The sample must go into a liquid.

3) It is usually not effective for identifying a compound. You must know what you are looking for to begin with.

4) It requires a new sample standard to be created every time you test with it, which leaves too much room for human error.

FACT #12: It is best to test creatine using the science of Spectroscopy because it measures a compound in its entirety, "as is", and also gives you the ability to identify the source materials. A good example of Spectroscopy testing method is the Near Infrared Analysis (NIR) and is the test of choice due to its speed and 100% reproducible accuracy.

NIR Testing Method

  • NIR tests a compound "as is", without any changes to the original sample.
  • NIR has much less chance for human error because it never needs a new standard once it is setup. It is stored indefinitely in the computer's memory.
  • With NIR, you do not need to know beforehand what you are looking for when analyzing a compound. With HPLC you do.
  • NIR is more accurate, usually within .01%. Kre-Alkalyn® EFX was discovered thanks to NIR.

Based on All These Points, We can Draw Some Powerful and Revealing Conclusions

Any "New and Improved" creatine product must have these 4 Critical Characteristics:

1. It must be made from Creatine Monohydrate.

2. It must be 100% stable in liquids so that it doesn't lose potency before reaching muscle.

3. It must bypass the problems caused by reacting finished Creatine Monohydrate all over again in water due to its instability.

4. It must be proven to be 100% pure and potent by using at least NIR and HPLC Analysis.

Kre-Alkalyn® EFX vs. Creatine Monohydrate

Creatine Monohydrate is the gold standard of creatine. And basedkre-alkalyn-efx on #4 Critical Criteria above any "new" creatine must come from this form. Even though Kre-Alkalyn® EFX could be considered a "new" creatine, it's still nearly identical to Creatine Monohydrate. Kre-Alkalyn® EFX is actually pure Creatine Monohydrate. 

Kre-Alkalyn® EFX vs. Creatine Ethyl Ester

This round of testing is to determine which form of creatine was the closest to Creatine Monohydrate. Of all the creatine products out there, the one that was examine was called Creatine Ethyl Ester. Creatine Ethyl Ester was tested to see how it chemically compares to Kre-Alkalyn® EFX and Creatine Monohydrate. BioCeuticals Research & Development Analytical Laboratory, in Montana, performed these tests under very strict conditions using Near Infrared Analysis (NIR).

The NIR machine's software was programmed to tabulate each analysis and measure it chemically against the overall standard: It confirms what was said earlier about most "new" creatines. At best, they are:

1) Ordinary Creatine Monohydrate labeled as something else.

2) A simple mixture of Creatine Monohydrate and the acid it's supposedly bonded with.

3) A botched version created by a manufacturer who tried to "bond" Creatine Monohydrate to an acid without knowing the associated problems.

Creatine Ethyl Ester lots are good examples of numbers 2 and 3 above, even though they do have some Creatine Monohydrate mixed in them.

The NIR test results concluded that Kre-Alkalyn® EFX is the "new and improved" version of Creatine Monohydrate.

All American EFX is First in Having Their Products Including Kre-Alkalyn® EFX Independently Screened for Drugs

All American EFX has established an industry first by having their products independently screened for drugs and steroids at the world's largest WADA-accredited Sports Testing Laboratory.

How Long Before Kre-Alkalyn® EFX Replaces Creatine?

The 12 Facts covered above all point to one logical conclusion, Kre-Alkalyn® EFX is the only creatine that's based on Creatine Monohydrate and doesn't have the same flaws.  200+ studies have already been performed using Creatine Monohydrate. It's firmly believe that it's not fully known the true power of creatine due to the flaws discussed before. It will be known its true potential as these same or similar studies are performed using Kre-Alkalyn® EFX.

Kre-Alkalyn® EFX is a Safer Form of Creatine

The best thing about Kre-Alkalyn® EFX is that you take lessflex_wheeler_natural_freak product overall. The average dosage size is 1.5 grams. Some may need to take 3 grams, but it's rare to ever exceed this amount.

By using this small amount it leads to much less creatinine being produced AFTER it's spent as fuel in your cells. The fact is much higher dosages of unstable ("non-buffered") creatine products just to get a decent amount into your muscle cells. Since it is unstable, this means you are taking in creatinine along with your creatine on the FRONT side, and that is a main concern.

There are studies that show creatine is safe overall. And for the most part it's agreed with.'s what most people don't know: 20 million Americans have some level of Chronic Kidney Disease (CKD). That's 1 out of every 9 adults. Even worse...there are also another 20 million estimated individuals out there who are at risk for kidney problems.  NOTE: These figures are from the National Kidney Foundation (

The real problem, as seen, is telling the masses that taking unstable creatine products is totally harmless...when it's not known who all these people are. And it is only logical that increasing the load on one's kidneys with excess creatinine certainly isn't going to help their situation. Kre-Alkalyn® EFX solves creatine's stability issue. So it makes sense to use it since the whole creatinine issue is also solved along with it.

The Bottom Line is Kre-Alkalyn® EFX is the "Best of the Best" Creatine

It has always been known and stated that conventional creatine is one the very best products ever to hit the market. However, if the flaws could be fixed (i.e., stabilize it), its effects could be compounded. Kre-Alkalyn® EFX has done this and has won "Best of The Best" creatine 2 years in a row. This very technology drew Flex Wheeler to All American EFX and he now backs it 100%. 

Note: For additional information about Kre-Alkalyn® EFX and other products by All American EFX check out

About the Author

lynn_glenn_expert_black_sleevelessLynn Glenn is a 61 year old natural athlete from Southern California who started training at the ripe young age of 48. After catching the "bodybuilding bug", Lynn Glenn became interested in living a healthy lifestyle and started writing about hot topics in the areas of health, fitness, weightlifting, and nutrition. Lynn is a feature writer for several health and fitness websites including, and



< Prev   Next >

 Contact Our News Editors

  • For any corrections of factual information, or to contact the editors please use our feedback form.
  • Please send any medical, health, fitness or anti-aging news press releases to: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it  
  Back to Front Page
 List of all Health and Medical Sections






A to Z Health:
Allergies | Alzheimers | Anxiety | Arthritis | Asthma | Attention Deficit Hyperactivity Disorder (ADHD) | Autism | Auto-Immune Disorders | Bird Flu | Bladder Cancer | Bone Disease | Brain Tumor Breast Cancer | Cardiovascular Disease | Cervical Cancer | Cholesterol (HDL, LDL) | Chronic Fatigue Syndrome | Cold and Flu | Colitis | Colon Cancer | Colorectal Cancer | Crohn's Disease Cystic Fibrosis | Dementia | Depression | Diabetes | Eczema | Endometrial Cancer | Erectile Dysfunction | Esophageal Cancer | Eye Disease | Fibromyalgia | Gastrointestinal Problems | Hair Loss Headaches (e.g., migraines, sinus, etc.) | Head and Neck | Hearing Loss | Heartburn | Heart Disease | Hormone Disorders | Hypertension (High Blood Pressure) | Infectious Diseases | Joint Pain Kidney Cancer | Kidney Disease | Leukemia | Liver Cancer | Liver Disease | Lung Cancer | Lung Disease | Lymphoma | Melanoma | Mesothelioma | Migraines | Multiple Sclerosis | Obesity Obessive Compulsive Disorder (OCD) | Osteoporosis | Ovarian Cancer | Pancreatic Cancer | Parkinson’s Disease | Pediatric Cancer | Prostate Cancer | Prostate Health | Psoriasis | Respiratory Ailments | Sarcoma | Skin Cancer | Skin Diseases & Conditions | Sleep Disorders | Stomach Cancer | Stress | Stroke | Testicular Cancer | Thyroid Cancer | Thyroid Disease | Urology/Renal

Visitors: 26188723
Copyright © 2007 - 2018 Muscle Mag Fitness | Muscle, Fitness and Health Resource All rights reserved. Use of this site constitutes acceptance of Muscle Mag Fitness terms of service.
Designed by: