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Dr. Jonathan Sack
Dr. Jonathan Sack
Dr. Jonathan Sack is a Board Certified Colon and Rectal Surgeon with over 20 years experience. Dr. Sak has been Associate Clinical Professor of Surgery at the David Geffen School of Medicine at UCLA since 2000 and specializes in Colon and Rectal Surgery. He is a Fellow of the American Society of Colon and Rectal Surgeons (F.A.S.C.R.S.) and of the American College of Surgeons (F.A.C.S.). He is also board Certified by the American Board of General Surgery. Dr.Sack is extremely knowledgeable regarding the GI system and is a recognized experts in his field.

Dr. Sack has extensive experience in treating patients with Colon and Rectal Cancer, Inflammatory Bowel Disease (including Crohn's disease and Ulcerative Colitis), as well as Anorectal Disorders and Pelvic Floor disorders. Dr. Sak is credentialed in Advanced Laparoscopic Surgery and Endoscopy.

Medical School Education

  • Institution: University of Florida - Year: 1978

Postdoctoral Education

  • University of Alabama at Bimingham, Alabama Resident General Surgery 1978-84
  • University of Virginia, Charlotteville, Virginia Research Fellow Gastrointestinal Surgery 1984-85
  • Saint Vincent Health Center, Erie, Pennsylvania Fellow Colon & Rectal Surgery 1998-99

Research Interests

Dr. Sack has clinical research interests in many aspects of colorectal surgery and colorectal cancer. He is an active co-investigator in several ongoing clinical trials. 

Clinical Interests

  • Colorectal Cancer
  • Inflammatory Bowel Disease 
  • Anorectal Surgery

Hospital Staff Appointments

  • UCAL - Westwood Campus 
  • UCLA - Santa Monica Hospital

Memberships in Scholarly or Professional Societies

  • American Society of Colon and Rectal Surgeons
  • Society for Surgery of the Alimentary Tract Fellow
  • American College of Surgeons American Gastroenterological Association
  • International Society for Digestive Surgery Society of American Gastrointestinal endoscopic Surgeons


“Lactobacillus Plantarum Undecaprenyl Pyrophosphate Synthetase: Purification and Reaction Requirements”, Allen, C.M., Keenan, M.V., SACK, J., Archives of Biochemistry and Biophysics, 175:236-248, 1976.

“CTP-Dependent Dolichol Phosphorylation by Mammalian Cell Homogenates”, Allen, C.M., Kalin, J.R., SACK, J., Veritzzo, D., Biochemistry, 17:5020-5026, 1978.

“Commentary (by invitation) on: Methods of Prophylaxis in Stress Ulcer Disease by Priebe, H.J. and Skillman, J.J”, SACK, J., Spenney, J.G., World Journal of Surgery, 5(2):229-231, 1981.

“A Proposed Mechanism for Thiocynate Inhibition of Acid Secretion”, SACK, J., Spenney, J.G., Surgical Forum, 33:128-130, 1982.

“Primary Mesenteric Venous Thrombosis”, SACK, J., Aldrete, J.S., Surgery, Gynecology & Obstetrics, 154:205-208, 1982.

“Aminopyrine Accumulation by Mammalian Gastric Glands: An Analysis of the Technique”, SACK, J., Spenney, J.G., American Journal of Physiology, 243:G313-G319, 1982.

“Secretagogue Stimulation of the Gastric Parietal Cell”, Jackson , R.J., Berglindh, T., Malinowska, D.H., SACK, J., Advances in Biosciences, Vol 33, Unvas, B. and Taska, K., Editors. Pergamon Press , New York , pp 153-166, 1982.

“Hepatocellular Carcinoma: Characteristics and Current Management”, SACK, J., Urist, M.M., Balch, C.M., Aldrete, J.S., Alabama Journal of Medical Sciences , 20(2):182-185, 1983.

“C-Kinase Mediated Acid Secretion in Gastric Glands”, SACK, J., Surgical Forum, 38:127-128, 1987.

“Current Trends in Liver Transplantation”, SACK, J., Aldrete, J.S., Diethelm, A.G., Alabama Journal of Medical Sciences , 25(1):78-81, 1988.

“Occlusion of Biliary Stents in Hepatic Transplantation Due to Cyclosporin Deposition”, SACK, J., Aldrete, J.S., Transplantation, 47(6):1068, 1989.

“Gastrointestinal Autonomic Nerve Tumors, Plexosarcomas”, Herrera, G.A., Cerezo, L., Jones, J.E., SACK, J., Grizzle, W.E., Pollack, W.J., Lott, R.L., Archives of Pathology and Laboratory Medicine, 113(8):846-853, 1989.

“The Effect of Verapamil on Insulin-Stimulated Choleresis”, SACK, J., Krusch, D.A., Hanks, J.B., Jones, R.S., Journal of Surgical Research, 49:88-91, 1990.

“Kool-Aid Colitis”, SACK, J., New England Journal of Medicine , 322(14):1012, 1990.

“Longtern Followup of 24 Patients Undergoing Radical Resection for Ampullary Carcinoma 1953-1988”, Schutze, W.P., SACK, J., Aldrete, J.S., Cancer, 66(8):1717-1720, 1990.

“Choledochoduodenostomy: Analysis of 71 Cases Followed From 5 to 15 Years”, Escudero-Fabre, A., Escallon, A.,Jr., SACK, J., Halpern, N.B., Aldrete, J.S., Annals of Surgery, 213(6):635-644, 1991.

“Isolation of a Gastric Protein Which Stimulates Acid Secretion”, SACK, J., Journal of Surgical Research, 53:166-169, 1992.

“Endoscopic Laser Therapy for Neoplastic Lesions of the Colorectum”, Escudero-Fabre, A., SACK, J., American Journal of Surgery, 163(2):260-262, 1992.

“Application of Endoscopic Injection Sclerotherapy to Gastric Varicies”, Escudero-Fabre, A., SACK, J., Halpern, N.B., Surgical Endoscopy, 6:93, 1992.

“Regulation of Gastric H +-K +-ATPase by cAMP-Dependent Protein Kinase: Isolation of a Novel Effector (Kayletin)”, SACK, J.,Journal of Surgical Research, 55:223-227, 1993.

“Primary Appendiceal Malignancies”, SACK, J., Current Surgery, 50(2):102-104, 1993.

“Colorectal Cancer: Natural History and Management”, SACK, J., Rothman, J.M., Hospital Physician, 36(10):64-73, 2000.

“Reporting Randomized Controlled Trials: Where Quality of Reporting May Be Improved”, Ko, C.Y., SACK, J., Chang, J.T., and Fink, A., Diseases of the Colon and Rectum, 45(4):443-447, 2002.

“Pathophysiology of Hemorrhoidal Disease”, SACK, J., Seminars in Colon and Rectal Surgery, 14(2); 93-99, 2003.

“Colonic Stent Versus Emergency Surgery in the Management of Acute Left-Sided Malignant Colon Obstruction: A Decision Analysis”, Targownik LE, Spiegel BM, SACK, J. et al, Gastrointestinal Endoscopy, 60(6); 865-874, 2004.

“A 10-year Outcomes Evaluation of Mucinous and Signet Ring Cell Carcinoma of the Colon and Rectum”, Kang H, O”Connell J, Maggard MA, SACK, J., and Ko CY, Diseases of the Colon and Rectum, 48(6); 1161-1168, 2005.

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