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Metabolic Syndrome Ups Colorectal Cancer Risk E-mail
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In a large U.S. population-based study presented at the 73rd Annual Scientific Meeting of the American College of Gastroenterology, metabolic syndrome patients had a 75 percent higher risk of colorectal cancer compared to those without metabolic syndrome.

Dr. Donald Garrow and Dr. Mark Delegge of the Medical University of South Carolina in Charleston analyzed data of patients who reported a history of metabolic syndrome and colorectal cancer from the National Health Interview Survey (NHIS), a comprehensive nationally representative study conducted each year by the National Center for Health Statistics.

Metabolic syndrome was defined as having a combination of three common chronic medical conditions: hypertension, diabetes and elevated cholesterol. The risk of colorectal cancer among patients with metabolic syndrome was determined by multivariate logistic regression analysis, controlling for age, race, gender, obesity, smoking and alcohol use.

“Since individuals with the metabolic syndrome have a significantly higher lifetime risk of colorectal cancer, they should closely adhere to published guidelines for colorectal cancer screening,” said Dr. Garrow.

About Metabolic Syndrome

Metabolic syndrome is also referred to as insulin resistance syndrome, syndrome X, dysmetabolic syndrome X, and Reaven syndrome.  
  • A quarter of the world's adults have metabolic syndrome
  • People with metabolic syndrome are twice as likely to die from, and three times as likely to have a heart attack or stroke compared with people without the syndrome
  • People with metabolic syndrome have a five-fold greater risk of developing type 2 diabetes
  • Up to 80% of the 200 million people with diabetes globally will die of cardiovascular disease. This puts metabolic syndrome and diabetes way ahead of HIV/AIDS in morbidity and mortality terms yet the problem is not as well recognized.
Metabolic syndrome is characterized by a group of conditions that increases a persons chance of developing:

All of these conditions are associated with high blood insulin levels. The fundamental defect in the metabolic syndrome is insulin resistance in both adipose tissue and muscle. Drugs that decrease insulin resistance also usually lower blood pressure and improve the lipid profile.

A person is considered having metabolic syndrome if they have any three of the following five conditions: 
  • High blood pressure (hypertension). >130 mm hg / 35 mm hg
  • Abnormal level of fasting blood glucose. > 100 mg/dl (or prediabetes which is between 100 - 125 mg/dl)
  • Increased weight around the waist. (apple shape rather than pear shape). Typically a waist measurement (apple shaped) >35" for women, > 40 " for man.
  • Elevated triglycerides. > 150 mg/dl
  • Low HDL ("good") cholesterol. <40 mg/dl men, < 50 mg/dl

Losing weight, eating a healthy diet, and exercising routinely can help to reduce your risk of metabolic syndrome.

New Education Tools From GI Experts Address Obesity and GI Disease

The American College of Gastroenterology recognizes that the epidemic of obesity is of particular relevance to gastroenterologists because of the clearly documented associations of obesity with a number of gastrointestinal disease risk factors and outcomes, including mortality rates and unfavorable risk profiles.

The ACG has developed new resource tools to help physicians incorporate patient education on the risks overweight and obesity. These educational resources on weight and GI health are available on the ACG Web site at www.acg.gi.org/obesity.

 
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