Skip to content

You are here:Home arrow Health and Medical arrow Diseases and Conditions arrow Alzheimers arrow Common Bacteria Linked to Alzheimer's Disease
Common Bacteria Linked to Alzheimer's Disease E-mail
Written by Administrator   

Researchers have shown a link between Chlyamydia pneumoniae and the amyloid plaques found in the brains of people with sporadic, non-hereditary Alzheimer's Disease.

The paper "Chlamydia pneumoniae induces Alzheimer-like Amyloid Plaques in Brains of BALB/c Mice," to be published in the April issue of Neurolobiology of Aging shows a link between the bacteria Chlyamydia pneumoniae and the amyloid plaques found in the brains of people who have sporadic, non-hereditary Alzheimer's Disease.

Researchers at Philadelphia College of Osteopathic Medicine's Center for the Study of Chronic Diseases of Aging have been studying a link between this common respiratory bacteria and pathology consistent with Alzheimer's Disease for several years. This most recent work builds on their ground-breaking research published in Medical Microbiology and Immunology in 1998 that discovered Chlamydia pneumoniae in 90 percent of brains taken from individuals who had suffered from Alzheimer's Disease. Their new work shows that the bacteria, when sprayed into the noses of mice not predisposed to amyloid plaques, can cause progressive deposition of amyloid plaques, in essence creating a partial model of Alzheimer's Disease.

"We believe this could be a trigger mechanism for the pathology in Alzheimer's Disease," says lead researcher Brian Balin, Ph.D. "People have been suspecting this for decades but could not find anything. It is very difficult to pinpoint an infectious cause for a progressive, chronic disease. We also believe that our isolation of Chlamydia pneumoniae from the human Alzheimer's Diseased brain and induction of pathology in normal mice is proof of principle that this can be a causative mechanism turning on pathology."

At one time, Alzheimer's was thought to be a hereditary disease. Research has shown that only two-to-five percent of Alzheimer's cases have a genetic tie. Fifty percent of people who reach age 85 will develop Alzheimer's

Balin is already looking further ahead. He wants to set up clinical trials in patients with late-onset AD to investigate the effect of typical antibiotics used for treating C. pneumoniae infections. But there is a lot of controversy now whether any existing antibiotics for C. pneumoniae can truly clear the organism from our bodies. "We try to intervene by using an antibiotic approach initially," says Balin. "I think it would offer hope to a patient that would have sporadic AD and would be diagnosed with having chlamydia infection as well. But in reality we are not sure whether the antibiotic approach will be sufficient to actually eradicate. Right now, we are thinking that combining antibiotics and anti-inflammatory drugs might be instrumental in treating AD, but obviously we do not have a final answer on that."

To access Neurobiology of Aging: http://www.sciencedirect.com/science/journal/01974580

About Alzheimer's Disease 

Alzheimer's disease (AD) is a slowly progressive disease of the brain that is characterized by impairment of memory and eventually by disturbances in reasoning, planning, language, and perception. Alzheimer's disease is the most common cause of dementia, which afflicts 24 million people worldwide. Alzheimer's disease is not a normal part of aging and is not something that inevitably happens in later life. It is rarely seen before the age of 65. The likelihood of having Alzheimer's disease increases substantially after the age of 70 and may affect around 50% of persons over the age of 85.  

 
< Prev   Next >

 Contact Our News Editors

  • For any corrections of factual information, or to contact the editors please use our feedback form.
  • Please send any medical, health, fitness or anti-aging news press releases to: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it  
  Back to Front Page
 List of all Health and Medical Sections

MMF RSS Feeds

Partners

Advertisement
Advertisement
Advertisement
 

Sponsors

Advertisement
Advertisement
Advertisement
Advertisement

A to Z Health:
Allergies | Alzheimers | Anxiety | Arthritis | Asthma | Attention Deficit Hyperactivity Disorder (ADHD) | Autism | Auto-Immune Disorders | Bird Flu | Bladder Cancer | Bone Disease | Brain Tumor Breast Cancer | Cardiovascular Disease | Cervical Cancer | Cholesterol (HDL, LDL) | Chronic Fatigue Syndrome | Cold and Flu | Colitis | Colon Cancer | Colorectal Cancer | Crohn's Disease Cystic Fibrosis | Dementia | Depression | Diabetes | Eczema | Endometrial Cancer | Erectile Dysfunction | Esophageal Cancer | Eye Disease | Fibromyalgia | Gastrointestinal Problems | Hair Loss Headaches (e.g., migraines, sinus, etc.) | Head and Neck | Hearing Loss | Heartburn | Heart Disease | Hormone Disorders | Hypertension (High Blood Pressure) | Infectious Diseases | Joint Pain Kidney Cancer | Kidney Disease | Leukemia | Liver Cancer | Liver Disease | Lung Cancer | Lung Disease | Lymphoma | Melanoma | Mesothelioma | Migraines | Multiple Sclerosis | Obesity Obessive Compulsive Disorder (OCD) | Osteoporosis | Ovarian Cancer | Pancreatic Cancer | Parkinson’s Disease | Pediatric Cancer | Prostate Cancer | Prostate Health | Psoriasis | Respiratory Ailments | Sarcoma | Skin Cancer | Skin Diseases & Conditions | Sleep Disorders | Stomach Cancer | Stress | Stroke | Testicular Cancer | Thyroid Cancer | Thyroid Disease | Urology/Renal

Visitors: 13867159
Copyright © 2007 - 2014 Muscle Mag Fitness | Muscle, Fitness and Health Resource All rights reserved. Use of this site constitutes acceptance of Muscle Mag Fitness terms of service.
Designed by: HostAfric.com