Skip to content

You are here:Home arrow Anti-aging arrow General Anti-aging Articles arrow Study Reports Popular Antiaging Supplement Has No Beneficial Effects
Study Reports Popular Antiaging Supplement Has No Beneficial Effects E-mail
Written by Administrator   

A widely used anti aging supplement has no effect on aging markers such as muscle strength, peak endurance, muscle mass, fat mass and glucose tolerance in elderly men and women, according to Mayo Clinic researchers. The findings from their two-year study appear in the Oct. 19, 2008 issue of the New England Journal of Medicine

The findings serve to dispel the belief that dehydroepiandrosterone (DHEA), sold extensively as an anti aging supplement in health and grocery stores, can reverse age-related alterations in body composition and function, says the study's lead author K. Sreekumaran Nair, M.D., Mayo Clinic endocrinologist.

"For almost two years we restored DHEA in older men and women to the high normal levels that are usually observed in young people, but found no beneficial effects on age-related changes in body composition and function," Dr. Nair says. "No beneficial effects on quality of life were observed. There's no evidence based on this study that DHEA has an antiaging effect."

The double blind study involved 87 men and 57 women who were followed for two years. Participants showed no change in several markers of aging -- body composition, physical performance, insulin sensitivity or quality of life.

Mayo Clinic's findings contradict some of the previous reports on DHEA. Dr. Nair says many former studies were done over shorter periods of time and didn't involve a large enough group of subjects. Mayo's study also was strengthened because it was a double blind, placebo-controlled, randomized trial. DHEA was administered only to people with low DHEA and testosterone levels.

Dr. Nair calls DHEA use a controversial issue, as antiaging supplements drive sales in the health food industry. He advises elderly people to stop using DHEA because it is unlikely to offer any antiaging effect.

DHEA has been promoted as an antiaging supplement, say the study's authors, in part because high levels of DHEA have been associated with longevity in humans and nonhuman primates. But studies involving rodents aren't applicable to humans, as rodents have very low levels of DHEA, the authors say.

The study also involved administering low-dose testosterone to elderly men who had low testosterone. The authors found testosterone offered minimal beneficial effects on bone density, and far less than those offered by many current accepted therapies. Investigators found no negative side effects, although they caution that the study was conducted only in men without prostate problems.

The New England Journal of Medicine published an accompanying editorial to Mayo's study, with Paul Stewart, M.D., of the University of Birmingham, Ala., saying the search for eternal youth will continue. But in light of the Mayo findings, he suggests DHEA should no longer be accepted as a food supplement and should instead be treated as a regulated drug.

"Appropriate regulation would dispel much of the quackery associated with this elusive hormone," Dr. Stewart writes.

Mayo's study was conducted by the study team without industry support.

The study's other authors are Robert Rizza, M.D.; Peter O'Brien, Ph.D.; Ketan Dhatariya, M.D.; Kevin Short, Ph.D.; Ajay Nehra, M.D.; Janet Vittone, M.D.; George Klee, M.D., Ph.D.; Ananda Basu, M.B.B.S.; Rita Basu, M.D.; Claudio Cobelli, Ph.D.; Gianna Toffolo, Ph.D.; Chiara Dalla Man, Ph.D.; Donald Tindall, Ph.D.; L.J. Melton, III, M.D.; Glenn Smith, Ph.D.; Sundeep Khosla, M.D.; and Michael Jensen, M.D.

 
< Prev   Next >

 Contact Our News Editors

  • For any corrections of factual information, or to contact the editors please use our feedback form.
  • Please send any medical, health, fitness or anti-aging news press releases to: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it  
  Back to Front Page
 List of all Health and Medical Sections

MMF RSS Feeds

Partners

Advertisement
Advertisement
Advertisement
 

Sponsors

Advertisement
Advertisement
Advertisement
Advertisement

A to Z Health:
Allergies | Alzheimers | Anxiety | Arthritis | Asthma | Attention Deficit Hyperactivity Disorder (ADHD) | Autism | Auto-Immune Disorders | Bird Flu | Bladder Cancer | Bone Disease | Brain Tumor Breast Cancer | Cardiovascular Disease | Cervical Cancer | Cholesterol (HDL, LDL) | Chronic Fatigue Syndrome | Cold and Flu | Colitis | Colon Cancer | Colorectal Cancer | Crohn's Disease Cystic Fibrosis | Dementia | Depression | Diabetes | Eczema | Endometrial Cancer | Erectile Dysfunction | Esophageal Cancer | Eye Disease | Fibromyalgia | Gastrointestinal Problems | Hair Loss Headaches (e.g., migraines, sinus, etc.) | Head and Neck | Hearing Loss | Heartburn | Heart Disease | Hormone Disorders | Hypertension (High Blood Pressure) | Infectious Diseases | Joint Pain Kidney Cancer | Kidney Disease | Leukemia | Liver Cancer | Liver Disease | Lung Cancer | Lung Disease | Lymphoma | Melanoma | Mesothelioma | Migraines | Multiple Sclerosis | Obesity Obessive Compulsive Disorder (OCD) | Osteoporosis | Ovarian Cancer | Pancreatic Cancer | Parkinson’s Disease | Pediatric Cancer | Prostate Cancer | Prostate Health | Psoriasis | Respiratory Ailments | Sarcoma | Skin Cancer | Skin Diseases & Conditions | Sleep Disorders | Stomach Cancer | Stress | Stroke | Testicular Cancer | Thyroid Cancer | Thyroid Disease | Urology/Renal

Visitors: 13364636
Copyright © 2007 - 2014 Muscle Mag Fitness | Muscle, Fitness and Health Resource All rights reserved. Use of this site constitutes acceptance of Muscle Mag Fitness terms of service.
Designed by: HostAfric.com